Depression Medication Names: Uses and Side Effects

Medically Reviewed:
Dr. Randy Gelow, MD, FASAM
Ray Hamilton, DNP, PMHNP-BC, FNP-C
Last Updated: February 9, 2025

Depression isn’t just sadness. It’s a serious condition that impacts millions. It can impact daily life, relationships, and overall well-being. While symptoms of depression vary from person to person, common signs include constant sadness, loss of interest in activities, low energy, and difficulty concentrating.

Depression treatment options include therapy, lifestyle changes, and medications. Antidepressant medications are often prescribed to help balance brain chemicals and improve mood. However, it is important to understand how they work, their potential side effects, and the different types available.

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What is Depression?

Depressive disorder, often referred to simply as depression, is a common but serious mental health condition that affects how a person thinks, feels, and behaves. It’s a mood disorder that causes persistent feelings of sadness, loss of interest, and can interfere with daily life. It goes beyond temporary sadness and can interfere with daily life, relationships, and work.

Symptoms of Depression:

  • Persistent feelings of sadness or emptiness
  • Loss of interest in activities once enjoyed
  • Changes in appetite and sleep patterns
  • Fatigue and low energy levels
  • Difficulty concentrating or making decisions
  • Feelings of worthlessness or guilt
  • Suicidal thoughts in severe cases

Causes and Risk Factors:

Depression is caused by a combination of factors, including:

  • Genetics – Family history of depression increases the risk.
  • Brain chemistry – Imbalance in neurotransmitters.
  • Hormonal changes – Pregnancy, menopause, and thyroid problems can contribute.
  • Stressful events – Trauma, loss of a loved one, or major life changes.
  • Medical conditions – Chronic illnesses like diabetes or heart disease.

How Do Antidepressants Work?

Antidepressants are generally safe and help regulate brain chemicals called neurotransmitters. These medications target serotonin, norepinephrine, and dopamine—key chemicals that affect mood and emotions.

  • SSRIs and SNRIs work by preventing the reabsorption (reuptake) of serotonin and norepinephrine, allowing more of these chemicals to be available for nerve cell communication.
  • TCAs and MAOIs influence multiple neurotransmitters, but their side effects make them less commonly prescribed today.

These medications help restore chemical balance, which can improve mood and reduce symptoms of depression.

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What are the Types of Antidepressants?

There are different types of antidepressants, but two of the most commonly used categories are SSRI and SNRI medications. These drugs help balance brain chemicals to improve mood and reduce symptoms of depression.

  • Selective Serotonin Reuptake Inhibitors (SSRIs)
  • Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)
  • Tricyclic Antidepressants (TCAs)
  • Monoamine Oxidase Inhibitors (MAOIs)
  • Atypical Antidepressants

Each of these medications has unique characteristics, benefits, and potential drawbacks. Below is a closer look at these types of antidepressants.

Common Depression Drugs and Anti Depression Medication Names

Selective Serotonin Reuptake Inhibitors (SSRIs)

SSRIs are some of the most commonly prescribed medications for depression. They help balance serotonin levels in the brain to improve mood and reduce symptoms of depression. Doctors widely prescribe these medications to treat depression and improve mood.

Common SSRIs include:

  • Fluoxetine (Prozac)
  • Sertraline (Zoloft)
  • Paroxetine (Paxil)
  • Citalopram (Celexa)
  • Escitalopram (Lexapro)

SSRIs are generally safe, with fewer side effects compared to older antidepressants. However, they may still cause side effects like nausea, dry mouth, and weight changes. In rare cases, too much serotonin in the brain can lead to serotonin syndrome, a serious health condition.

Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)

SNRIs work similarly to SSRIs but also affect norepinephrine levels, which can help with both depression and anxiety.

Common SNRIs include:

  • Venlafaxine (Effexor XR)
  • Duloxetine (Cymbalta)
  • Desvenlafaxine (Pristiq)
  • Levomilnacipran (Fetzima)

SNRIs work by improving neurotransmitter balance, making them effective for treating depression and certain chronic pain conditions. However, they can cause side effects such as dizziness, increased heart rate, and excessive sweating.

Tricyclic Antidepressants (TCAs)

TCAs were among the first antidepressants developed. Although they are effective, they tend to have more side effects than SSRIs and SNRIs.

Some well-known TCAs include:

  • Amitriptyline
  • Nortriptyline (Pamelor)
  • Imipramine (Tofranil)

TCAs can be helpful for severe depression but may cause drowsiness, weight gain, and dry mouth. They are usually prescribed when newer medications are not effective.

Monoamine Oxidase Inhibitors (MAOIs)

MAOIs are less commonly prescribed due to their potential interactions with food and other medications. However, they are effective for certain types of depression.

Common MAOIs include:

  • Phenelzine (Nardil)
  • Tranylcypromine (Parnate)
  • Isocarboxazid (Marplan)

People taking MAOIs must follow strict dietary restrictions to avoid dangerous side effects.

Atypical Antidepressants

Atypical antidepressants do not fit into the traditional categories but still help treat depression. Some examples include:

  • Bupropion (Wellbutrin) – Increases dopamine and norepinephrine levels, often used for smoking cessation as well.
  • Mirtazapine (Remeron) – Helps with sleep issues and appetite stimulation.
  • Trazodone – Often prescribed for sleep problems rather than depression itself.

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How Long Do Antidepressants Take to Work?

Antidepressants do not work immediately. Most people start seeing improvements within 2 to 4 weeks, but it may take 6 to 8 weeks for full benefits.

If you feel no changes, do not stop taking your medication suddenly. Instead, speak with a doctor about adjusting the dosage or switching to another safe antidepressant.

Antidepressant Side Effects

While antidepressants are generally safe, they can cause various side effects. Some common side effects include:

  • Dry mouth
  • Nausea
  • Weight gain or loss
  • Drowsiness or insomnia
  • Dizziness

In some cases, individuals may experience more severe reactions, including serotonin syndrome or an increase in suicidal thoughts, particularly in young adults. If any unusual symptoms occur, it is essential to seek medical attention.

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What Happens If You Stop Taking Antidepressants Suddenly?

Stopping antidepressants suddenly can lead to withdrawal symptoms, such as:

  • Dizziness
  • Flu-like symptoms
  • Irritability
  • Anxiety
  • Brain zaps (electric shock sensations in the brain)

To avoid these symptoms, it is best to gradually reduce the dosage under a doctor’s supervision.

Beyond Medication: Other Depression Treatment Options

Medication is just one approach to treating depression. Other depression treatment options include:

  • Therapy
  • Brain stimulation therapy
  • Lifestyle changes
  • Support groups

Finding Safe Antidepressants

Choosing the right antidepressant depends on individual needs, medical history, and potential side effects. While most antidepressants are generally safe, some people may need to try different medications to find the one that works best for them. Consulting a healthcare provider can help determine the most suitable treatment plan.

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Mental Treatment Near Me

Depression can feel overwhelming, but effective treatments are available. Whether you need common depression drugs or therapy, there are options to help you feel better. Learning about antidepressant medications, their side effects, and how they work can empower you to make informed decisions about your mental health. Learning about the list of depression medication names, how antidepressants work, and their side effects can help in making informed decisions.

If you or someone you love is struggling, reach out for support today. The Hope House offers expert care and personalized treatment plans. From common depression drugs to therapy options, we’ll help you find the right path to recovery.

Take control of your mental health today. Explore depression medications with expert insights.